The supplement's primary goal is to examine critical issues in science, technology and innovation and in science-based international development. The articles are written by prominent scientists, many from the developing world, who are either members of TWAS or researchers who have worked closely with TWAS over the years. Visit (and download) the supplement online at www.nature.com. -- The current issue of Nature (455, 30 October 2008) carries an editorial ('Growing stronger') arguing that "science in developing countries can withstand the current economic climate".